A group of researchers at the Department of Periodontics, Indiana University School of Dentistry, 1121 West Michigan Street, DS 423, Indianapolis, IN 46202 studied the effects of Calendula on human gingival fibroblast (HGF) mediated collagen degradation and MMP activity.
They found that Calendula inhibits HGF-mediated collagen degradation and MMP-2 activity more than the corresponding concentration of quercetin - which is often thought to be the most important ingredient.
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